Drugs
Ebasal / δ (constitutive activity %)
n (transducer slope)
R (receptor reserve, log scale)
Stimulus response
Stimulus responseReceptor occupancy
Receptor occupancySummary
| Drug | logKi | ε | EC50 | Emax |
|---|
Equations
n (transducer slope)
R (receptor reserve, log scale)
Name
log Ki (M)
εA (intrinsic efficacy, %)
log Ki (M)
εB (intrinsic efficacy, %)
0% = neutral antagonist
[B] concentration series
Lowest log[B] (M)
Log increment
Number of [B] curves
3
Stimulus response
Stimulus responseReceptor occupancy (Drug A)
Receptor occupancy (Drug A)Summary
| Curve | EC50 | Emax | DR |
|---|
Schild plot
Equations
R is adjustable for illustrative purposes only. Keep log R = 0 for quantitative use.
Curve shape
Graph title
X-axis label
X-axis range
Y-axis label
Y-axis range
Maximum
Minimum
Slope
Position
Potency
Maximum
Minimum
Additional curves
0
Association x-axis range (min)
Dissociation x-axis range (min)
log kon,L (M−1min−1)
log koff,L (min−1)
KD
10 nMlog [L*] (M)
10 nM
Association
Dissociation
Summary
Equations